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Betel-derived nitrogen-doped multicolor carbon dots for environmental and biological applications
This study presents a new way to detect iron (Fe3+) ions in biological and environmental samples for health and environmental protection purposes. A green and water-soluble nitrogen-doped carbon dot from betel leaf was used as a probe. It had excellent selectivity and sensitivity and was quick to detect Fe3+ ..
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Axitinib versus placebo as an adjuvant treatment of renal cell carcinoma: results from the phase III, randomized ATLAS trial
Axitinib, an oral medication, has proven useful in the treatment of advanced renal cell carcinoma (RCC) after the failure of one therapy. Its efficacy and safety were evaluated in the ATLAS trial, whose results showed that there was no significant change in disease-free survival rates with the use of axitinib..
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Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
Cancerous tumors often become resistant to single drugs, prompting a search for effective cancer-targeted therapy combinations. To accelerate this search, a DREAM Challenge was launched in association with AstraZeneca and the Sanger Institute. 160 teams participated to propose synergistic combinations of drug..
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A decline in emissions of CFC-11 and related chemicals from eastern China
In 2013, a rise in trichlorofuoromethane (CFC-11) emissions was reported in eastern China. Using observations and simulations, researchers found that CFC-11 emissions in China had returned to pre-2013 levels by 2019. This reduction implies that the ozone layer recovery has been maintained, potentially due to ..
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Halotolerant bacteria mitigate the effects of salinity stress on soybean growth by regulating secondary metabolites and molecular responses
High salt levels are harmful to plant growth and agriculture. There is thus a need for a natural, eco-friendly way to improve crop growth in saline conditions. Now, researchers have found a way to do this. When two specific strains of rhizobacteria (ALT29 and ALT43) were applied to soybean seedlings, they wer..
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Exogenous melatonin induces drought stress tolerance by promoting plant growth and antioxidant defence system of soybean plants
Melatonin, a hormone commonly associated with the sleep cycle in humans, may also have implications in agriculture. A recent study showed that melatonin reduced oxidative damage and increased photosynthetic activity in soybean seedlings, improving their resilience to drought.
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Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus
The genetic associations and susceptible locii for systemic lupus erythematosus (SLE), a highly heritable autoimmune disorder, are yet to be completely explained, and more data for East Asian populations is required. So, researchers conducted a study—the largest genome-wide meta-analysis for SLE in East Asi..
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Efficacy and Safety of Intravenous Mesenchymal Stem Cells for Ischemic Stroke
Autologous modified mesenchymal stem cells (MSCs) could enhance recovery for patients with chronic major stroke. In a recent study comparing patients with stroke who received preconditioned autologous MSC injections to those who received standard treatment, MSC treatment led to improved leg motor function.
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PRODIGY: A Phase III Study of Neoadjuvant Docetaxel, Oxaliplatin, and S-1 Plus Surgery and Adjuvant S-1 Versus Surgery and Adjuvant S-1 for Resectable Advanced Gastric Cancer
Neoadjuvant therapeutic regimens—which involve the intensification of chemotherapy and other adjuvant treatment for cancer—have garnered worldwide interest, and are being actively developed in different countries. Evidence from a recent Korean study indicates that neoadjuvant chemotherapy can significantl..